Colson Smith (Craig Tinker), Sue Cleaver (Eileen Grimshaw), Luca Toolan (Mason Radcliffe), and Sue Devaney (Debbie Webster) are among those either leaving or having already been phased out.
Sean Wilson was controversially axed in September due to a historical sex claim, only to be later exonerated.
He was slated to reprise his role as Martin Platt as part of the departure storyline for Gail Platt, played by Helen Worth.
